Andrew G Bowie Selected Research

Pattern Recognition Receptors

1/2021	Detection of Viral Infections by Innate Immunity.
1/2020	PYHIN1 regulates pro-inflammatory cytokine induction rather than innate immune DNA sensing in airway epithelial cells.
11/2019	Toll-like receptor 2-dependent endosomal signaling by Staphylococcus aureus in monocytes induces type I interferon and promotes intracellular survival.
1/2018	Poxviral protein E3-altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor-stimulated immune responses.
8/2015	Poxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-B Activation by Targeting p65 for Degradation.
12/2014	The emerging role of human PYHIN proteins in innate immunity: implications for health and disease.
10/2014	Innate immune activation of NFκB and its antagonism by poxviruses.
2/2014	Innate antiviral signalling in the central nervous system.
8/2013	Innate immune detection of microbial nucleic acids.
9/2011	Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7.

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Andrew G Bowie Research Topics

Disease

17	Porcine Reproductive and Respiratory Syndrome (PRRS) 01/2021 - 10/2005
10	Infections 01/2022 - 12/2004
8	Virus Diseases (Viral Diseases) 01/2021 - 12/2004
8	Bites and Stings (Sting) 01/2020 - 11/2010
6	Inflammation (Inflammations) 01/2018 - 02/2008
3	Melanoma (Melanoma, Malignant) 12/2014 - 04/2007
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 05/2015
1	Blindness (Hysterical Blindness) 01/2022
1	Bacterial Infections (Bacterial Infection) 01/2022
1	Idiopathic Pulmonary Fibrosis 01/2022
1	Pseudomonas Infections 01/2022
1	Retinal Degeneration 01/2022
1	Disease Progression 01/2022
1	Cerebral Malaria 11/2021
1	COVID-19 01/2021
1	Multiple Sclerosis 01/2019
1	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2019
1	Sepsis (Septicemia) 01/2019
1	Neoplasms (Cancer) 01/2018
1	Malaria 12/2017
1	Mumps 01/2017
1	Human Influenza (Influenza) 01/2017
1	Hepatitis C 01/2017
1	Gliosis 05/2015
1	Poxviridae Infections 10/2014
1	Colorectal Neoplasms (Colorectal Cancer) 08/2014
1	Smallpox (Variola) 02/2013
1	Central Nervous System Infections (Central Nervous System Infection) 10/2012
1	Autoimmune Diseases (Autoimmune Disease) 04/2012
1	Vaccinia 10/2010
1	Necrosis 06/2008
1	Lung Diseases (Lung Disease) 12/2005

Drug/Important Bio-Agent (IBA)

19	Pattern Recognition ReceptorsIBA 01/2021 - 10/2005
12	Proteins (Proteins, Gene)FDA Link 01/2020 - 12/2005
12	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 11/2010
10	Toll-Like Receptors (Toll-Like Receptor)IBA 11/2019 - 10/2005
9	CytokinesIBA 01/2021 - 12/2004
8	InterferonsIBA 01/2021 - 08/2008
5	Antiviral Agents (Antivirals)IBA 01/2022 - 04/2012
5	Pathogen-Associated Molecular Pattern MoleculesIBA 01/2021 - 02/2008
4	RNA (Ribonucleic Acid)IBA 01/2021 - 04/2007
4	DNA receptor (receptor, DNA)IBA 01/2018 - 02/2008
4	Nucleic AcidsIBA 05/2015 - 04/2007
3	InflammasomesIBA 01/2021 - 04/2012
3	Tretinoin (Retinoic Acid)FDA LinkGeneric 02/2014 - 10/2005
3	Double-Stranded RNA (RNA, Double Stranded)IBA 10/2011 - 10/2005
2	Viral DNAIBA 01/2021 - 08/2010
2	PyrinIBA 01/2020 - 12/2014
2	Transcription Factors (Transcription Factor)IBA 01/2018 - 12/2017
2	UbiquitinIBA 01/2018 - 01/2017
2	Interferon Type IIBA 03/2016 - 08/2013
2	NucleotidesIBA 02/2014 - 04/2006
2	RNA Helicases (RNA Helicase)IBA 02/2008 - 10/2005
2	eIF-2 Kinase (eIF 2 Kinase)IBA 02/2008 - 04/2007
1	FlagellinIBA 01/2022
1	Toll-Like Receptor 3IBA 01/2022
1	Caspase 3 (Caspase-3)IBA 01/2022
1	sodium iodateIBA 01/2022
1	Toll-Like Receptor AgonistsIBA 01/2022
1	16S Ribosomal RNAIBA 01/2022
1	Chemokine CXCL10IBA 11/2021
1	Interferon LambdaIBA 01/2021
1	Adenosine Monophosphate (AMP)IBA 01/2020
1	LipopolysaccharidesIBA 01/2019
1	Etoposide (VP 16)FDA LinkGeneric 01/2018
1	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2018
1	TNF Receptor-Associated Factor 6 (TRAF6)IBA 01/2018
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2018
1	Phosphotransferases (Kinase)IBA 12/2017
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 01/2017
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2017
1	Small Interfering RNA (siRNA)IBA 01/2017
1	ChitosanIBA 03/2016
1	Vaccine AdjuvantsIBA 03/2016
1	AntigensIBA 03/2016
1	Immunoglobulins (Immunoglobulin)IBA 03/2016
1	PolymersIBA 03/2016
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2015
1	Differentiation AntigensIBA 12/2014
1	NLR ProteinsIBA 02/2014
1	Interleukin-1 (Interleukin 1)IBA 12/2010
1	Peptides (Polypeptides)IBA 10/2010
1	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA 08/2008
1	I-kappa B KinaseIBA 08/2008
1	NF-kappa B (NF-kB)IBA 06/2008
1	Viral ProteinsIBA 02/2008
1	beta-DefensinsIBA 04/2006
1	DefensinsIBA 04/2006
1	ErbB Receptors (EGF Receptor)IBA 04/2006
1	Protein Kinases (Protein Kinase)IBA 12/2004

Therapy/Procedure

2	Therapeutics 01/2022 - 01/2019